منابع مشابه
Phorbol esters enhance exocytosis from chromaffin cells by two mechanisms.
Treatment with phorbol esters such as 12-O-tetradecanoylphorbol acetate (TPA) rapidly enhances [3H]norepinephrine secretion from digitonin-permeabilized adrenal chromaffin cells. When TPA treatment was prolonged for several hours, a second distinct enhancing effect was observed. This later enhancement was most prominent at intracellular Ca2+ concentrations of 3-30 microM, and did not require th...
متن کاملTumor-promoting Phorbol Esters
The effect of tumor-promoting phorbol esters on the in vitro proliferation of mouse pluripotent hematopoietic stem cells (CFU-S) was examined using a short-term in vitro culture system and an 11-d spleen colony assay. Phorbol myristate acetate (PMA, 10-7 M), but not the inert compound phorbol, supported the in vitro survival of day 11 CFU-S for 72 h in a manner similar to IL 3. PMA also enhance...
متن کاملMembrane effects of phorbol esters.
SUMMARY Tetradecanoyl-phorbol-acetate (TPA) was observed to produce a 15% decrease in the electrophoretic mobility of hyperdiploid Ehrlich-Lettré ascites tumor cells (ELD). This reduction in mobility of ELD was capable of being reversed by washing the cells in Ca2@-free Krebs-Ringer phosphate. An inactive phorbol stereoisomer (4a-phorbol-didecanoate) did not reduce the mobility of ELD. Effects...
متن کاملGrowth Factors and Phorbol Esters
Insulin-like growth factor I (IGF I) is an important mitogen for vascular smooth muscle cells. To characterize regulation of vascular IGF I receptors, we performed radioligand displacement experiments using rat aortic smooth muscle cells (RASMs). Serum deprivation for 48 hours caused a 401% decrease in IGF I receptor number. Exposure of quiescent RASMs to platelet-derived growth factor (PDGF), ...
متن کاملTwo New Phorbol-Type Diterpene Esters from Synadenium grantii Hook F. Leaves
Two new phorbol-type diterpene esters have been isolated from the chloroform extract of the leaves of Synadenium grantii Hook F. and identified as 3,4,12,13-tetraacetylphorbol-20-phenylacetate and 4deoxyphorbol-12,13-ditiglate for which the trivial names Synagrantol A & B respectively, were adopted. Furthermore, two known triterpenes were isolated. The structures of all isolated compounds were ...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2007
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x0700200203